Mining Putative Regulatory Elements in Gene Promoter Regions

This study attempts to discover putative binding site on how combinations of the known regulatory sites and over-represented repetitive elements are distributed in the promoter regions of groups of functionally related genes. The association rules mined would facilitate to predict putative regulatory elements and identify genes potentially co-regulated by the putative regulatory elements. The over-represented repetitive elements appearing in the associations found are possible to be putative TF binding sites or the other regulatory signals correlated to the occurrences of known TF binding sites. The proposed approach is applied to Saccharomyces cerevisiae and the promoter regions of Yeast ORFs from its gene annotations. The reader may refer to http://regdb.csie.ncu.edu.tw/ for the further result and information.